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Literature summary for 2.7.11.1 extracted from

  • Halvarsson, C.; Eliasson, P.; Joensson, J.
    Pyruvate dehydrogenase kinase 1 is essential for transplantable mouse bone marrow hematopoietic stem cell and progenitor function (2017), PLoS ONE, 12, e0171714 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [pyruvate dehydrogenase (acetyl-transferring)] Mus musculus
-
 ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9Z2A0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hematopoietic stem cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyruvate dehydrogenase complex
-
 Mus musculus ADP + phosphorylated pyruvate dehydrogenase complex
-
 ?
ATP + [pyruvate dehydrogenase (acetyl-transferring)]
-
 Mus musculus ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PDK1
-
 Mus musculus
pyruvate dehydrogenase kinase 1
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus hypoxia upregulates isoform PDK1. Isoform Pdk1 expression is upregulated by hypoxia inducible factor 1alpha during hypoxic culture of LSK cells in vitro up

General Information

General Information Comment Organism
physiological function isoform PDK1 activity is crucial for transplantable hematopoietic stem cell function. Isoform PDK1 has broad effects in hematopoiesis and is a critical factor for engraftment of both hematopoietic stem cells and multipotent progenitors upon transplantation to recipient mice Mus musculus